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Research & Development

Modular Technology Platform and Approaches

We use a high efficiency, high-yield modular product development technology platform.


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Progress of Discovery

l  The best iPSC line has been banked and supplied for gene editing work

l  Gene editing system (Cas9/sgRNA with homologous arm DNA template) and methods have been optimized and validated for 5 different loci

l  Hypothesis driven editing have been completed for 4 genes, 2 of them have functional validation already

l  CAR cassette has been constructed to test various combination of design elements for better activity in NK

l  Binder sequences for 8 different solid tumor targets are being screened, 3 of them have been inserted into CAR as scFv,, and in vitro killing activity have been demonstrated


Development of Innovative Process

l  Closed system in bioreactor for continuous differentiation and expansion

l  QbD, high quality standards to ensure a robust process for consistence

l  Serum-free, feeder cell-free

l  CAR cassette has been constructed to test various combination of design elements for better activity in NK

l  Production scale: balancing the risk and cost, aiming to produce > 100 dose/batch

l  Final product purity > 95%, cryo-thawing recovery > 85%


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Progress of Process Development

l  Completed small scale entire process from iPSC to iNK, with expected yield, purity and activity

l  Process optimization and scale up are in process


R&D and Manufacturing centre

A fully equipped state-of-art 60,000 sqf facility including Discovery labs, Process sciences, GMP clean rooms and QC labs is in operation. 


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